❞ كتاب Enrofloxacin to Control Anaplasma marginale Infections ❝

Enrofloxacin to Control Anaplasma marginale Infections

Enrofloxacin to Control Anaplasma marginale Infections من كتب طب بيطرى

Enrofloxacin
to
Control
Anaplasma
marginale
Infect ions
A.
A.
GUGLIELMONE,"
0.
S.
ANZIANI,"
A.
J.
MANGOLD,"
M. M.
VOLPOGN1,b
AND
A.
VOGEL"
"Estacidn Experimental
Agropccuaria
Rafaela
Instituto
Nacional
de
Tecnologia Agropecuaria
cc
22
CP
2300
Rafaela,
Santa
Fe, Argentina
bFacultad
de
Agronornia
y Veterinaria
Universidad
Nacional
del
Litoral
Kreder
2805
CP
3080
Esperanza,
Santa
Fe,
Argentina
'Bayer
Argentina
S.A.
Divisidn Veterinaria
General
Rivas
2466
CP
I41
7,
Buenos
Aires,
Argentina
Anaplasmosis
(Anaplasma marginale)
is a common disease
in
South American cattle
raised
north
to 33"s. Oxytetracycline
or
imidocarb is
usually
applied to treat clinical
cases
of anaplasmosis.
It has
been
recently reported
that the
fluorquinolon enrofloxacin
was effective in controlling infections with
A.
marginale
in
South Africa.' This report
describes
an
experiment to control anaplasmosis
in
the
increasing parasitemia phase
of
the disease.
Fifteen Holstein steers
(15 months
old), free
of
antibodies against
A.
marginale
(card agglutination test)2
were
inoculated
with
200
million erythrocytes infected
with
the
A.
marginale
strain
S1P
(no
appendage^)^
of
Argentinean origin. Eight steers
were randomly allocated to the treated group (TG)
and
medicated
with
10
mg
of
enrofloxacin
per
kg
of
body
weight for two consecutive days
when the
parasitemia
reached a minimum
of 3% of
the
red cells.
The
other 7 steers formed the control
group
(CG).
They
were
treated
with
20
mg
per
kg
of
body
weight
of
a long acting
oxytetracycline
when the
hematocrit
index
reached a value
of
15%
to avoid deaths.
The
steers
of
the
TG
developed a parasitemia
of
at
least 3% of the red cells
in
a mean
period
of
22.9
?
2.03 days,
range:
21-27
days.
The average parasitemia
2
SD
and range on the
day
of
the
first treatment
with
enrofloxacin was
4.5
?
2.27%
(3.0-
10.0%).
Seventy-four hours after the second treatment, the parasitemia values
were
0.9
2
0.76%
(0.1-2.0%)
(p
<
0.01,
"t"
test
with
angular transformation;
the
figures presented are nontransform values).
The
parasitemia found 72 h after the
second enrofloxacin treatment
was
also significantly
lower
(p
c
0.01)
than that found
in
the
CG
(10.0
t
6.14%,
1.0-20.0%)
on
the equivalent day. Six
of
the steers
of
the
CG
were treated
with
oxytetracycline due to severe anemia on days
25
to
30 . المزيد..